GLPwatch
Byetta vs Trulicity
Drug comparison
Last updated 2026-05-28 15:46 UTCByetta (exenatide by AstraZeneca) and Trulicity (dulaglutide by Eli Lilly) are both injectable medications for type 2 diabetes, given under the skin. Byetta is approved only to treat type 2 diabetes, while Trulicity is also approved to lower cardiovascular risk in people with type 2 diabetes. The main difference is their active ingredients—exenatide versus dulaglutide—and their makers.
AI summary of the sources below.
| Byetta | Trulicity | |
|---|---|---|
| Active ingredient | exenatide | dulaglutide |
| Manufacturer | astrazeneca | eli-lilly |
| Route | subcutaneous injection | subcutaneous injection |
| FDA-approved for | type 2 diabetes | type 2 diabetes, cardiovascular risk reduction |
| Label updated | 2025-09-02 | 2023-08-05 |