GLPwatch
Ozempic vs Rybelsus
Drug comparison
Last updated 2026-05-28 15:46 UTCOzempic and Rybelsus both contain the same active ingredient, semaglutide, and are made by Novo Nordisk, but they are taken differently: Ozempic is a once-weekly injection under the skin, while Rybelsus is a daily pill taken by mouth. Both are FDA-approved to treat type 2 diabetes, but Ozempic is also approved to reduce cardiovascular risk and treat chronic kidney disease.
AI summary of the sources below.
| Ozempic | Rybelsus | |
|---|---|---|
| Active ingredient | semaglutide | semaglutide |
| Manufacturer | novo-nordisk | novo-nordisk |
| Route | subcutaneous injection | oral |
| FDA-approved for | type 2 diabetes, cardiovascular risk reduction, chronic kidney disease | type 2 diabetes |
| Label updated | 2026-01-30 | 2026-01-30 |