GLPwatch
Rybelsus vs Soliqua
Drug comparison
Last updated 2026-05-28 15:46 UTCRybelsus is an oral medication containing semaglutide, made by Novo Nordisk, and is FDA-approved to treat type 2 diabetes. Soliqua is an injectable medication containing lixisenatide, made by Sanofi, and is also FDA-approved to treat type 2 diabetes. The main differences are that Rybelsus is taken by mouth, while Soliqua is given as a shot under the skin.
AI summary of the sources below.
| Rybelsus | Soliqua | |
|---|---|---|
| Active ingredient | semaglutide | lixisenatide |
| Manufacturer | novo-nordisk | sanofi |
| Route | oral | subcutaneous injection |
| FDA-approved for | type 2 diabetes | type 2 diabetes |
| Label updated | 2026-01-30 | 2026-03-18 |