Rybelsus vs Trulicity

Drug comparison

Last updated 2026-05-28 15:46 UTC

Rybelsus (semaglutide by Novo Nordisk) is an oral pill for type 2 diabetes, while Trulicity (dulaglutide by Eli Lilly) is a once-weekly injection for the same condition and also to lower cardiovascular risk. The main differences are how they're taken—one is a daily pill, the other a weekly shot—and their active ingredients, semaglutide versus dulaglutide.

AI summary of the sources below.

	Rybelsus	Trulicity
Active ingredient	semaglutide	dulaglutide
Manufacturer	novo-nordisk	eli-lilly
Route	oral	subcutaneous injection
FDA-approved for	type 2 diabetes	type 2 diabetes, cardiovascular risk reduction
Label updated	2026-01-30	2023-08-05

Compare full details on the Rybelsus and Trulicity pages.