GLPwatch

Semaglutide vs Tirzepatide

Molecule comparison

Last updated 2026-05-28 15:46 UTC

Semaglutide (brand names Ozempic, Wegovy, Rybelsus) is a GLP-1 receptor agonist approved to treat type 2 diabetes, obesity, chronic kidney disease, and cardiovascular risk reduction. Tirzepatide (brand names Mounjaro, Zepbound) is a dual GIP and GLP-1 receptor agonist approved for type 2 diabetes, obesity, and obstructive sleep apnea. Both are taken as injections, but Semaglutide is also available as a pill (Rybelsus), while Tirzepatide is only available as an injection.

AI summary of the sources below.

Semaglutide Tirzepatide
MechanismGLP-1 receptor agonistGIP and GLP-1 receptor dual agonist
StatusApprovedApproved
Branded productsozempic, wegovy, rybelsusmounjaro, zepbound

Compare full details on the Semaglutide and Tirzepatide pages.