GLPwatch
Trulicity vs Zepbound
Drug comparison
Last updated 2026-05-28 15:46 UTCTrulicity (dulaglutide) and Zepbound (tirzepatide) are both injectable medications made by Eli Lilly, but they treat different conditions: Trulicity is approved for type 2 diabetes and reducing cardiovascular risk, while Zepbound is approved for obesity and obstructive sleep apnea. The main difference is their active ingredients—Trulicity uses dulaglutide, while Zepbound uses tirzepatide.
AI summary of the sources below.
| Trulicity | Zepbound | |
|---|---|---|
| Active ingredient | dulaglutide | tirzepatide |
| Manufacturer | eli-lilly | eli-lilly |
| Route | subcutaneous injection | subcutaneous injection |
| FDA-approved for | type 2 diabetes, cardiovascular risk reduction | obesity, obstructive sleep apnea |
| Label updated | 2023-08-05 | 2026-04-22 |