Acute Systemic Complications Following High-Dose Semaglutide Reinitiation in an Elderly Patient.

Severe gastrointestinal intolerance with systemic complications can occur within hours of reinitiating high-dose semaglutide after a prolonged treatment interruption, even in patients who previously tolerated the medication. Elderly patients with comorbidities may be particularly vulnerable. Clinicians should consider re-titration from lower doses when restarting GLP-1 receptor agonists after drug holidays to minimize severe adverse effects.