The Vascular Effects of Exenatide Versus Metformin in Patients With Pre-Diabetes

NCT00546728 · Completed

Last updated 2026-05-28

This clinical trial compared the effects of the medication exenatide to metformin on blood vessel function in adults with pre-diabetes over a 3-month period.

Status Completed The study has finished.

Phase Phase 4 Monitors a drug already on the market.

Type Interventional (clinical trial)

Design Randomized, open-label (no blinding) treatment study

Participants 50 people

Who can join Ages 18+ · all sexes

Timeline Started 2007-10 · est. completion 2011-07

Where 2 sites · United States

What this study is testing ClinicalTrials.gov NCT00546728 ↗

Description as written by the study sponsor.

The purpose of this study is to compare the effects of exenatide versus metformin on vascular health with chronic (3-month) therapy and during a 2-hour period following a meal in patients with pre-diabetes. It is predicted that exenatide will improve vascular health to a greater degree compared to metformin.

Treatments tested

Exenatide Drug

exenatide 10 mcg twice daily
Metformin Drug

metformin 500 twice daily

Main thing measured	Change in Reactive Hyperemic Index Over the 3-month Treatment Period
Sponsor	St. Paul Heart Clinic
Conditions studied	Impaired Glucose Tolerance
GLP-1 drugs	exenatide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT00546728 ↗