Cooperation of Insulin and GLP-1 on Myocardial Glucose Uptake

NCT01232946 · Completed

Last updated 2026-05-28

This clinical trial is testing how insulin and GLP-1 work together to improve glucose uptake in the heart of adults with type 2 diabetes.

Status Completed The study has finished.

Phase Not applicable Not a phased drug trial (e.g. a device or behavioral study).

Type Interventional (clinical trial)

Design Randomized, open-label (no blinding) study

Participants 30 people

Who can join Ages 18–50 · all sexes

Timeline Started 2012-01 · est. completion 2017-09

Where 1 site · United States

What this study is testing ClinicalTrials.gov NCT01232946 ↗

Description as written by the study sponsor.

27 Type 2 diabetic subjects (HbA1c 7.5 - 9.5%) currently treated with diet and exercise alone or with oral antidiabetic agents will be randomly assigned to one of three treatment groups: insulin detemir, liraglutide, or liraglutide plus detemir (9 subjects per group), on a background of metformin 2000 mg per day. After 3 months' treatment, PET measurements of myocardial fuel selection will take place, under fasting conditions in the morning following that day's treatment injection(s).

Treatments tested

liraglutide also known as Victoza Drug

1.8mg subcutaneous qd for 3 months
insulin detemir also known as Levemir Drug

5units subcutaneous bid titrated to fasting glucose of \<130mg/dL for 3 months
liraglutide plus insulin detemir also known as Vyctoza plus Levemir Drug

liraglutide 1.8mg subq qd plus insulin detemir 5units bid titrated to fasting blood glucose \<130mg/dL for 3 months.

Main thing measured	Myocardial Glucose Uptake
Sponsor	Indiana University
Conditions studied	Type 2 Diabetes
GLP-1 drugs	—

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT01232946 ↗