Comparison of Liraglutide Inhaled Into the Lungs Compared to Liraglutide Injected Under the Skin in Healthy Male Volunteers

NCT01511159 · Completed

Last updated 2026-05-28

This clinical trial compares the effects of inhaled liraglutide (a diabetes medication) versus injected liraglutide in healthy adult men.

Status Completed The study has finished.

Phase Phase 1 Checks safety and dosing in a small group.

Type Interventional (clinical trial)

Design Randomized, open-label (no blinding) treatment study

Participants 32 people

Who can join Ages 18–45 · male only

Timeline Started 2001-10 · est. completion 2001-12

Where 1 site · United Kingdom

What this study is testing ClinicalTrials.gov NCT01511159 ↗

Description as written by the study sponsor.

This trial is conducted in Europe. The aim of this trial is to determine the relative bioavailability of NNC 90-1170 (liraglutide) when inhaled compared to NNC 90-1170 when injected under the skin.

Treatments tested

liraglutide Drug

Single dose of 6 mcg/kg by inhalation. Progression to open-label trial part will be based on safety data
placebo Drug

Single dose by inhalation. Progression to open-label trial part will be based on safety data
liraglutide Drug

Single dose of 12 mcg/kg by inhalation. Subjects receive treatment in random order
liraglutide Drug

Single dose 6 mcg/kg injected subcutaneously. Subjects receive treatment in random order
insulin human Drug

Single dose 0.4 IU/kg by inhalation. Subjects receive treatment in random order
insulin human Drug

Single dose 0.08 IU/kg injected subcutaneously. Subjects receive treatment in random order
liraglutide also known as NNC 90-1170 Drug

24 mcg/kg by inhalation. Progression to dose level will be based on safety evaluation

Main thing measured	Ratio of the areas under the plasma NN 90-1170 curves
Sponsor	Novo Nordisk A/S
Conditions studied	Diabetes, Healthy
GLP-1 drugs	liraglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT01511159 ↗