A Study to Compare the Effect of Giving Dulaglutide Using an Auto-injector Versus a Manual Syringe

NCT01524770 · Completed

Last updated 2026-05-28

This study is testing how well a diabetes medication called dulaglutide is absorbed in the body when given using an auto-injector compared to a manual syringe in adults with type 2 diabetes.

Status Completed The study has finished.

Phase Phase 1 Checks safety and dosing in a small group.

Type Interventional (clinical trial)

Design Randomized, open-label (no blinding) treatment study

Participants 50 people

Who can join Ages 18+ · all sexes Healthy volunteers accepted.

Timeline Started 2012-03 · est. completion 2012-06

Where 1 site · United States

What this study is testing ClinicalTrials.gov NCT01524770 ↗

Description as written by the study sponsor.

The study involves 2 injections of 1.5 milligrams (mg) dulaglutide, 1 given by a pre-filled manual syringe, the other given by an auto-injector. Injections will be separated by a minimum 28-day washout period. The study will evaluate if the levels of drug in the blood are similar when given by each method. Participation in the study is likely to take approximately 7 weeks, not including screening.

Treatments tested

Dulaglutide also known as LY2189265 Biologic

Administered by subcutaneous (SC) injection

Main thing measured	Pharmacokinetics: Area Under the Concentration Curve (AUC[0-336]) for Dulaglutide
Sponsor	Eli Lilly and Company
Conditions studied	Diabetes Mellitus, Type 2
GLP-1 drugs	dulaglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT01524770 ↗