Effects of Victoza® Versus Lyxumia® on Gastroesophageal Reflux, Gastric Emptying and Gastric Acid Secretion

NCT02231658 · Terminated

Last updated 2026-05-28

This clinical trial compares the effects of Victoza® and Lyxumia® on acid reflux, stomach emptying, and stomach acid production in adults with diabetes.

Status Terminated Stopped early and will not restart.

Phase Phase 1 Checks safety and dosing in a small group.

Type Interventional (clinical trial)

Design Randomized, single-blind treatment study

Participants 109 people

Who can join Ages 18–65 · all sexes

Timeline Started 2015-07 · est. completion 2018-07

Where 2 sites · Germany

What this study is testing ClinicalTrials.gov NCT02231658 ↗

Description as written by the study sponsor.

The present study will compare lixisenatide and liraglutide in a population of subjects with T2DM not optimally controlled on OADs and / or insulin, which is the target population for these medications.

Treatments tested

Liraglutide Drug
Lixisenatide Drug

Main thing measured	Change from baseline (week -1) in the number of reflux episodes
Sponsor	Profil Institut für Stoffwechselforschung GmbH
Conditions studied	Diabetes Mellitus
GLP-1 drugs	liraglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT02231658 ↗