Investigating the Influence of Omeprazole on the Pharmacokinetics of Oral Semaglutide in Healthy Subjects

NCT02249871 · Completed

Last updated 2026-05-28

This clinical trial is testing how the medication omeprazole affects the levels of semaglutide in the bloodstream of healthy adults.

Status Completed The study has finished.

Phase Phase 1 Checks safety and dosing in a small group.

Type Interventional (clinical trial)

Design Randomized, open-label (no blinding) treatment study

Participants 54 people

Who can join Ages 18–75 · all sexes Healthy volunteers accepted.

Timeline Started 2014-09 · est. completion 2015-04

Where 1 site · Germany

What this study is testing ClinicalTrials.gov NCT02249871 ↗

Description as written by the study sponsor.

This trial is conducted in Europe. The aim of this trial is to investigate the influence of omeprazole on the pharmacokinetics (the exposure of the trial drug in the body) of oral semaglutide in healthy subjects.

Treatments tested

semaglutide Drug

All subjects will be treated for 10 consecutive days including dose escalation, with 5 days on 5 mg oral semaglutide followed by 5 days on 10 mg oral semaglutide.
Omeprazole Drug

Will be given daily with oral semaglutide.

Main thing measured	Area under the semaglutide plasma concentration time curve
Sponsor	Novo Nordisk A/S
Conditions studied	Diabetes, Healthy
GLP-1 drugs	semaglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT02249871 ↗