Efficacy and Safety of Oral Semaglutide Versus Placebo in Subjects With Type 2 Diabetes Mellitus Treated With Diet and Exercise Only

NCT02906930 · Completed

Last updated 2026-05-28

This clinical trial tested the effects of an oral diabetes medication called semaglutide compared to a placebo in adults with type 2 diabetes who manage their condition with diet and exercise alone.

Status Completed The study has finished.

Phase Phase 3 Confirms effectiveness in a large group before approval.

Type Interventional (clinical trial)

Design Randomized, double-blind treatment study

Participants 703 people

Who can join Ages 18+ · all sexes

Timeline Started 2016-09 · est. completion 2017-12

Where 105 sites · Algeria, Bulgaria, Czechia, Italy, Japan, Mexico, Romania, Russia, Serbia, Turkey (Türkiye), United States

What this study is testing ClinicalTrials.gov NCT02906930 ↗

Description as written by the study sponsor.

This trial is conducted globally. The aim of this trial is to investigate efficacy and safety of oral semaglutide versus placebo in subjects with type 2 diabetes mellitus treated with diet and exercise only.

Treatments tested

semaglutide Drug

Oral administration once daily.
placebo Drug

Oral administration once daily.

Main thing measured	Change in HbA1c
Sponsor	Novo Nordisk A/S
Conditions studied	Diabetes, Diabetes Mellitus, Type 2
GLP-1 drugs	semaglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT02906930 ↗