A Trial Investigating the Effect of Oral Semaglutide on the Pharmacokinetics of Furosemide and Rosuvastatin in Healthy Subjects

NCT03010475 · Completed

Last updated 2026-05-28

This trial tests how a diabetes medication called oral semaglutide affects the levels of two other drugs, furosemide and rosuvastatin, in healthy adults.

Status Completed The study has finished.

Phase Phase 1 Checks safety and dosing in a small group.

Type Interventional (clinical trial)

Design open-label (no blinding) treatment study

Participants 41 people

Who can join Ages 18–65 · all sexes Healthy volunteers accepted.

Timeline Started 2017-01 · est. completion 2017-08

Where 1 site · United Kingdom

What this study is testing ClinicalTrials.gov NCT03010475 ↗

Description as written by the study sponsor.

This trial is conducted in Europe. Tha aim of this trial is to investigate the effect of oral semaglutide on the pharmacokinetics of furosemide and rosuvastatin in healthy subjects.

Treatments tested

Furosemide Drug

Oral administration A total of three single doses.
Rosuvastatin Drug

Oral administration. A total of three single doses.
SNAC Drug

Oral administration. A total of five single doses.
Semaglutide Drug

Oral administration. Once daily.

Main thing measured	Area under the furosemide plasma concentration-time curve
Sponsor	Novo Nordisk A/S
Conditions studied	Diabetes, Healthy
GLP-1 drugs	semaglutide

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT03010475 ↗