Pistachio Intake and Nutrition-Related Outcomes in Individuals on GLP-1 Therapy

NCT07244445 · Recruiting

Last updated 2026-05-28

This clinical trial tests whether eating pistachios affects feelings of hunger and fullness in adults who are overweight or obese and taking GLP-1 medications.

Status Recruiting Currently enrolling participants.

Phase Not applicable Not a phased drug trial (e.g. a device or behavioral study).

Type Interventional (clinical trial)

Design Randomized, open-label (no blinding) supportive care study

Participants 108 people Planned (estimated).

Who can join Ages 18–80 · all sexes Healthy volunteers accepted.

Timeline Started 2026-01 · est. completion 2027-12

Where 1 site · United States

What this study is testing ClinicalTrials.gov NCT07244445 ↗

Description as written by the study sponsor.

In this study will look at how eating pistachios every day might affect participants weight, how healthy their diet is, and how they feel when eating. Investigators want to see if adding pistachios to meals for 12 weeks helps participants feel fuller, have more energy, and improve body composition. The study will include adults who have been taking GLP-1 medicines like semaglutide or tirzepatide for at least three months. Investigators also want to see if eating pistachios improves overall diet quality and health markers like tiredness and certain levels in blood.

Treatments tested

Pistachios Dietary supplement

Participants will eat 2 ounces, or about 53 grams, of dry-roasted, unsalted pistachios each day along with their regular diet
Dual-energy X-ray absorptiometry (DEXA) scans Procedure

DEXA scans will be used to measure body fat

Main thing measured	Change is Satiety as measured by the Hunger and Satiety Visual Analog Scales (VAS)
Sponsor	Ian J. Neeland, MD
Conditions studied	Dietary Change, Obesity & Overweight, Food Acceptance
GLP-1 drugs	—

Full protocol, eligibility, and contacts on ClinicalTrials.gov NCT07244445 ↗